Collagenase Injection for Dupuytren’s Contracture

Collagenase clostridium histolyticum (brand name XIAFLEX) is an enzyme injection used to treat Dupuytren’s contracture. The enzyme works by dissolving a small portion of the thick cord allowing the physician to straighten the finger. Not every person is a candidate for the injection, and the cord does not completely dissolve.

After the insurance company gives approval for use of the enzyme, the hand is numbed in the office and the injection is placed into the thick cord that is holding the finger down. The night after the injection, the hand will become bruised and swollen. In the next day or two one returns to the office and, after numbing the area, the finger is straightened. Therapy and splinting are started soon after to help keep the finger out straight.